- Sabater, Norberto
- Saiz, Pedro
- Salaam, Ali
- Saladin, Tony
- Salava, James
- Salazar, Mario
- Salazar, Richard
- Saleem, Faruq
- Salem, Kabary
- Salerno, James
- Salerno, Jerry
- Salka, Rod
- Sally, Daniel
- Samir, Ahmed
- Sanabria, Alex
- Sanchez, Enrique
- Sanchez, Joe
- Sanchez, Julio
- Sanders, Bear
- Sanders, Germaine
- Sandoval, Richie
- Santana, Luis
- Santana, Miguel
- Santiago, Carlos
- Santiago, Joe
- Santiago, Luis Alberto
- Santos, Wilson
- Savage, Harry
- Savannah, Frank
- Schilling, Mike
- Schrack, Brian
- Scott, James
- Scott, Malik
- Scott, Reshawn
- Scott, Robert
- Scott, Terry
- Scully, Jim
- Scully, John
- Scypion, Wilford
- Seaborn, Kevin
- Seabrooks, Kelvin
- Seay, Terry
- Segura, Pancho
- Senquiz, Margaro
- Sepulveda, Ray
- Serrano, Ray
- Sesay, Ben
- Shabazz, Khalif
- Shabazz, Muhammad
- Shakir, Calvin
- Sharmon, Ken
- Sharpe, Andre
- Shaw, Dawud
- Sheehan, Dan
- Sheffield, Brandon
- Sheika, Omar
- Sherrick, Monty
- Shoffner, Al
- Shorter, Felix
- Shorts, Paul
- Silva, David
- Simmons, Floyd
- Simmons, Mark
- Simon, O'Donnell
- Simonyan, Artyom
- Sims, Henry
- Sims, Jeff
- Sindo, Angel
- Singh, Gurcharan
- Singletary, Ernie
- Smith r, Bonecrusher
- Smith, Aaron
- Smith, Anthony Caputo
- Smith, Antwone
- Smith, Bonecrusher
- Smith, Charles
- Smith, Charlie
- Smith, Dhafir
- Smith, Don
- Smith, Ed
- Smith, Jake
- Smith, Joshua
- Smith, Paul
- Smith, Robert
- Smith, Scot
- Smith, Toneo
- Smith, Troy
- Smith, Zach
- Snow, Thomas
- Soler, Joey
- Soliman, Rafael
- Solis , Julian
- Solis, Julian
- Solis, Ramon
- Solomon, King
- Sosa, Jason
- Soto, Jose
- Soto, Jose Vidal
- Soto, Ray
- Spadafora, Paul
- Spain, Darryl
- Spain, Ricardo
- Spears, Joseph
- Speight, Exum
- Spinks, Michael
- St. Kitt, Felix
- Stackhouse, Ricky
- Stanton, James
- Starnino, Richard
- Staton, Sterling
- Steamboat, Ricky
- Stephens, Anthony
- Stern, Tony
- Stevenson, Ronnie
- Stevenson, Troy
- Stewart , Leslie
- Stewart, Felix Bernell
- Stewart, Howard
- Stewart, John
- Stewart, Mike
- Stewart, Richard
- Stills, James
- Sting Like a, Maccabee
- Stinson, Marvin
- Stoner Jones, Russell
- Strickland, Jay
- Strickland, Reggie
- Strohman, Ernest
- Sturm, Chuck
- Suero, Tony
- Sullivan, Carl
- Summit, Curtis
- Sumners, Joe
- Sutton, Anthony
- Sykes, Jimmie
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